Hayek LabUniversity of Texas Medical Branch

Publications

228 publications since 2008, 81 of them as first or senior author: 169 reports of original research and 59 reviews, chapters, editorials and guidelines.

29,891 citations, h-index 64, i10-index 168. Google Scholar, 2026-11-03

Search all 228 publications

Eleven papers that define the lab's research.

  1. 2026

    uPAR/suPAR Signaling and Organ Crosstalk in Cardiovascular-Kidney-Metabolic Syndrome

    Circulation ResearchsuPAR & Inflammatory BiomarkersFirst author

    Comprehensive mechanistic review reframing uPAR/suPAR as compartmentalized signaling system in CKM syndrome: membrane uPAR drives local inflammation/remodeling, soluble suPAR mediates remote organ injury via αvβ3-integrin/RAGE activation

  2. 2024

    AHA scientific statement providing comprehensive guidance on cardiovascular evaluation, risk stratification, and management across all phases of hematopoietic stem cell transplantation from pretransplant assessment through long-term survivorship

  3. 2023

    The 100-day and 5-year cumulative incidence of CV events after HSCT were 4.1% and 13.9%; allogeneic recipients had higher incidence of long-term CV events compared to autologous recipients (16.4% vs 12.1%).

  4. 2023

    The D2D3 form of uPAR acts as an immunotoxin and may cause diabetes and kidney disease

    Science Translational MedicinesuPAR & Inflammatory BiomarkersCo-author

    D2D3 uPAR fragment impairs pancreatic beta-cell function and causes glomerular injury in transgenic mice; anti-uPAR antibody restores beta-cell mass and function.

  5. 2023

    Thymic epithelial tumors were associated with 18-fold higher ICI-myocarditis risk, earlier onset, higher mortality (64% vs 23% at 30 days), and more severe myotoxicities compared to other cancers.

  6. 2022

    ICI myocarditis incidence was 1.0%; CPK elevation was sensitive (99%) for myocarditis and predicted all-cause mortality independent of cardiac biomarkers.

  7. 2022

    Increased soluble urokinase plasminogen activator levels modulate monocyte function to promote atherosclerosis

    Journal of Clinical InvestigationsuPAR & Inflammatory BiomarkersSenior author

    suPAR levels predict coronary calcification and CVD events; GWAS identified PLAUR rs4760 variant causing elevated suPAR; Mendelian randomization shows causality; suPAR-transgenic mice develop larger atherosclerotic plaques via proinflammatory monocyte priming

  8. 2020

    Soluble Urokinase Receptor (SuPAR) in COVID-19–Related AKI

    Journal of the American Society of NephrologysuPAR & Inflammatory BiomarkersSenior author

    Admission suPAR levels predicted AKI and dialysis need in 352 COVID-19 patients; highest tertile had 9.15-fold increased AKI odds and 22.86-fold dialysis odds, independent of inflammatory markers.

  9. 2020

    Soluble Urokinase Receptor and Acute Kidney Injury

    New England Journal of MedicinesuPAR & Inflammatory BiomarkersFirst author

    Highest suPAR quartile associated with 2.66-fold higher odds of AKI; suPAR overexpression in mice worsened contrast-induced AKI; anti-uPAR antibody attenuated kidney injury, establishing suPAR as biomarker and therapeutic target

  10. 2017

    APOL1 G1/G2 risk variants conferred CKD risk only when suPAR elevated; mechanistically, APOL1 variants bind suPAR-activated αvβ3 integrin with higher affinity, causing podocyte injury.

  11. 2015

    Soluble Urokinase Receptor and Chronic Kidney Disease

    New England Journal of MedicinesuPAR & Inflammatory BiomarkersFirst author

    Higher suPAR predicted 3.1-fold increased incident CKD risk and greater eGFR decline, with annual decline of -4.2 ml/min/1.73m² in highest quartile versus -0.9 in lowest.

Everything, 2008 to 2026.

Topic
All topics10 topics
Years
Role

Showing all 228 publications.

Full publication record by year. The topic, role and search filters do not change these totals. Select a bar to filter the list. Inflammation & Organ Injury 138Cardio-Oncology 52Other 38
Publications per year by program
YearInflammation & Organ InjuryCardio-OncologyOther
2008001
2011200
2013105
2014507
2015608
20161002
20171307
2018624
2019452
20201440
20212071
20221960
20231180
20241091
2025840
2026970

202616 papers

202512 papers

202420 papers

202319 papers

202225 papers

202128 papers

202018 papers

201911 papers

201812 papers

201720 papers

201612 papers

201514 papers

201412 papers

20136 papers

20112 papers

20081 paper